Publications

o Sarikaya, M., Tamerler, C., Jen, A. K. Y., Schulten, K., & Baneyx, F. (2003) Molecular biomimetics: nanotechnology through biology. Nature Materials, 2(9), 577-585.

The first study on Molecular Biomimetics that introduced the new convergent science and technology paradigm to the literature

o Paine, M. L., Zhu, D. H., Luo, W., Bringas Jr, P., Goldberg, M., White, S. N., Lei, Y., Sarikaya, M., Fong, H. K. & Snead, M. L. (2000) Enamel biomineralization defects result from alterations to amelogenin self-assembly. Journal of Structural Biology, 132(3), 191-200.

A compilation of studies using molecular biomimetics and an introduction of the field to the materials scientists, chemical engineers, condensed matter physics, and technologists

o Dogan, S., Fong, H., Yucesoy, D. T., Cousin, T., Gresswell, C., Dag, S., Huang, G. & Sarikaya, M. (2018) Biomimetic tooth repair: amelogenin-derived peptide enables in vitro remineralization of human enamel. ACS Biomaterials Science & Engineering, 4(5), 1788-1796.

The first study showing  the remineralization of damaged human enamel using an convergent science designed ADP

o Gungormus, M., Oren, E. E., Horst, J. A., Fong, H., Hnilova, M., Somerman, M. J., Snead, M. L., Samudrala, R., Tamerler, C. & Sarikaya, M. (2012) Cementomimetics—constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides. International Journal of Oral Science, 4(2), 69-77.

The first paper demonstrating the formation of cementomimetic layer on the worn out root of  human tooth, and  showing the binding and proliferation of PDL cells, a step towards PDL regeneration.

o Yucesoy, D. T., Fong, H., Gresswell, C., Saadat, S., Chung, W. O., Dogan, S., & Sarikaya, M. (2018) Early caries in an in vivo model: structural and nanomechanical characterization. Journal of Dental Research, 1452-1459.

A study of altering amelogenin to recognize structural defects in a transgenic animal. A detailed study of caries formation in an animal model that could serve as  a standard model for future  studies for caries formation and remineralization.

o Fong, H., Sarikaya, M., White, S. N., & Snead, M. L. (1999) Nano-mechanical properties profiles across dentin–enamel junction of human incisor teeth. Materials Science and Engineering: C, 7(2),119-128.

The first study on the structure and nanomechanical properties of dentin-enamel junction with high spatial resolution in both imaging and structural mechanics

o Paine, M. L., Zhu, D. H., Luo, W., Bringas Jr, P., Goldberg, M., White, S. N., Lei, Y., Sarikaya, M., Fong, H. K. & Snead, M. L. (2000) Enamel biomineralization defects result from alterations to amelogenin self-assembly. Journal of Structural Biology, 132(3), 191-200.

A study of altering amelogenin to recognize structural defects in a transgenic animal

o Gungormus, M., Fong, H., Kim, I. W., Evans, J. S., Tamerler, C., & Sarikaya, M. (2008) Regulation of in vitro calcium phosphate mineralization by combinatorially selected hydroxyapatite-binding peptides. BioMacromolecules, 9(3), 966-973.

The first demonstration of the HAp binding peptides in biomineralization.

o Khatayevich, D., Gungormus, M., Yazici, H., So, C., Cetinel, S., Ma, H., Jen, A., Tamerler, C. & Sarikaya, M. (2010) Biofunctionalization of materials for implants using engineered peptides. Acta Biomaterialia, 6(12), 4634-4641.

The use of SBP/GEPI in functionalizing the surfaces of implants using solid binding peptide-based heterofunctional molecular constructs

o Yucesoy, D. T., Khatayevich, D., Tamerler, C., & Sarikaya, M. (2020) Rationally designed chimeric solid‐binding peptides for tailoring solid interfaces. Medical Devices & Sensors, 3(3), e10065.

A study reviewing the applications of heterofunctional solid-binding peptides for device and sensor application, in particular immobilizing functional probes design for specific molecular targets and biomarkers.

o Yazici, H., O’Neill, M. B., Kacar, T., Wilson, B. R., Oren, E. E., Sarikaya, M., & Tamerler, C. (2016) Engineered chimeric peptides as antimicrobial surface coating agents toward infection-free implants. ACS Applied Materials & Interfaces, 8(8), 5070-5081.

Demonstration of a use of antimicrobial peptide conjugated to ADP5 in  AM coating of  Ti-implants  demonstrating antimicrobial activity towards oral microbiome.